Caren L. Freel Meyers: search on Z-Library

The world's largest scientific articles store. 70,000,000+ articles for free.

1

Enamide Prodrugs of Acetyl Phosphonate DXP Synthase Inhibitors as Potent Antibacterial Agents

Bartee, David, Sanders, Sara, Phillips, Paul D, Harrison, Mackenzie J., Koppisch, Andrew T., Freel Meyers, Caren L.

Journal:

ACS Infectious Diseases

Year:

2019

Language:

english

File:

PDF, 950 KB

english, 2019

2

In Silico Dose Prediction for Long-Acting Rilpivirine and Cabotegravir Administration to Children and Adolescents

Rajoli, Rajith K. R., Back, David J., Rannard, Steve, Meyers, Caren Freel, Flexner, Charles, Owen, Andrew, Siccardi, Marco

Journal:

Clinical Pharmacokinetics

Year:

2017

Language:

english

File:

PDF, 1.85 MB

english, 2017

3

Synthesis and Evaluation of Fluoroalkyl Phosphonyl Analogs of 2-C-Methylerythritol Phosphate as Substrates and Inhibitors of IspD from Human Pathogens

Bartee, David, Wheadon, Michael J., Freel Meyers, Caren L.

Journal:

Journal of Organic Chemistry

Year:

2018

Language:

english

File:

PDF, 1.43 MB

english, 2018

4

Challenges and Hallmarks of Establishing Alkylacetylphosphonates as Probes of Bacterial 1-Deoxy- d -xylulose 5-Phosphate Synthase

Sanders, Sara, Vierling, Ryan J., Bartee, David, DeColli, Alicia A., Harrison, Mackenzie J., Aklinski, Joseph L., Koppisch, Andrew T., Freel Meyers, Caren L.

Journal:

ACS Infectious Diseases

Year:

2017

Language:

english

File:

PDF, 2.46 MB

english, 2017

5

Conformational dynamics of 1-deoxy-d-xylulose 5-phosphate synthase on ligand binding revealed by H/D exchange MS

Zhou, Jieyu, Yang, Luying, DeColli, Alicia, Freel Meyers, Caren, Nemeria, Natalia S., Jordan, Frank

Journal:

Proceedings of the National Academy of Sciences

Year:

2017

Language:

english

File:

PDF, 1.36 MB

english, 2017

6

Initial Characterization of Novobiocic Acid Noviosyl Transferase Activity of NovM in Biosynthesis of the Antibiotic Novobiocin †

Freel Meyers, Caren L., Oberthür, Markus, Anderson, John W., Kahne, Daniel, Walsh, Christopher T.

Journal:

Year:

2003

Language:

english

File:

PDF, 153 KB

english, 2003

7

Identification of an Atg8-Atg3 Protein–Protein Interaction Inhibitor from the Medicines for Malaria Venture Malaria Box Active in Blood and Liver Stage Plasmodium falciparum Parasites

Hain, Adelaide U.P., Bartee, David, Sanders, Natalie G., Miller, Alexia S., Sullivan, David J., Levitskaya, Jelena, Meyers, Caren Freel, Bosch, Jürgen

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 4.76 MB

english, 2014

8

DXP Synthase-Catalyzed CN Bond Formation: Nitroso Substrate Specificity Studies Guide Selective Inhibitor Design

Morris, Francine, Vierling, Ryan, Boucher, Lauren, Bosch, Jürgen, Freel Meyers, Caren L.

Journal:

Year:

2013

Language:

english

File:

PDF, 433 KB

english, 2013

9

Observation of Thiamin-Bound Intermediates and Microscopic Rate Constants for Their Interconversion on 1-Deoxy- d -xylulose 5-Phosphate Synthase: 600-Fold Rate Acceleration of Pyruvate Decarboxylation by d -Glyceraldehyde-3-phosphate.

Patel, Hetalben, Nemeria, Natalia S., Brammer, Leighanne A., Freel Meyers, Caren L., Jordan, Frank

Journal:

Journal of the American Chemical Society

Year:

2012

Language:

english

File:

PDF, 795 KB

english, 2012

10

Semi-solid prodrug nanoparticles for long-acting delivery of water-soluble antiretroviral drugs within combination HIV therapies

Hobson, James J., Al-khouja, Amer, Curley, Paul, Meyers, David, Flexner, Charles, Siccardi, Marco, Owen, Andrew, Meyers, Caren Freel, Rannard, Steve P.

Journal:

Nature Communications

Year:

2019

File:

PDF, 1.28 MB

2019

11

Redox-dependent lipoylation of mitochondrial proteins in P lasmodium falciparum

Afanador, Gustavo A., Matthews, Krista A., Bartee, David, Gisselberg, Jolyn E., Walters, Maroya S., Freel Meyers, Caren L., Prigge, Sean T.

Journal:

Molecular Microbiology

Year:

2014

Language:

english

File:

PDF, 1.60 MB

english, 2014

12

Methylerythritol cyclodiphosphate (MEcPP) in deoxyxylulose phosphate pathway: synthesis from an epoxide and mechanisms

Xiao, Youli, Nyland II, Rodney L., Meyers, Caren L. Freel, Liu, Pinghua

Journal:

Chemical Communications

Year:

2010

Language:

english

File:

PDF, 609 KB

english, 2010

13

X-ray crystallography–based structural elucidation of enzyme-bound intermediates along the 1‑deoxy‑d‑xylulose 5-phosphate synthase reaction coordinate

Chen, Percival Yang-Ting, DeColli, Alicia A., Freel Meyers, Caren L., Drennan, Catherine L.

Journal:

Journal of Biological Chemistry

Year:

2019

Language:

english

File:

PDF, 4.09 MB

english, 2019

14

The Crystal Structure of the Novobiocin Biosynthetic Enzyme NovP: The First Representative Structure for the TylF O-Methyltransferase Superfamily

Inmaculada Gómez García, Clare E.M. Stevenson, Isabel Usón, Caren L. Freel Meyers, Christopher T. Walsh, David M. Lawson

Journal:

Journal of Molecular Biology

Year:

2010

Language:

english

File:

PDF, 3.99 MB

english, 2010

15

Probing phosphorylation by non-mammalian isoprenoid biosynthetic enzymes using 1H–31P–31P correlation NMR spectroscopy

Majumdar, Ananya, Shah, Meha H., Bitok, J. Kipchirchir, Hassis-LeBeau, Maria E., Freel Meyers, Caren L.

Journal:

Molecular BioSystems

Year:

2009

Language:

english

File:

PDF, 2.18 MB

english, 2009

16

2 C -Methyl- d -erythritol 4-Phosphate Enhances and Sustains Cyclodiphosphate Synthase IspF Activity

Bitok, J. Kipchirchir, Meyers, Caren Freel

Journal:

ACS Chemical Biology

Year:

2012

Language:

english

File:

PDF, 646 KB

english, 2012

17

Characterisation of Streptomyces spheroides NovW and revision of its functional assignment to a dTDP-6-deoxy-d-xylo-4-hexulose 3-epimerase

Tello, Mónica, Jakimowicz, Piotr, Errey, James C., Freel Meyers, Caren L., Walsh, Christopher T., Buttner, Mark J., Lawson, David M., Field, Robert A.

Journal:

Chemical Communications

Year:

2006

Language:

english

File:

PDF, 395 KB

english, 2006

18

Inside Cover: IspG-Catalyzed Positional Isotopic Exchange in Methylerythritol Cyclodiphosphate of the Deoxyxylulose Phosphate Pathway: Mechanistic Implications (ChemBioChem 4/2011)

Dr. Youli Xiao, Debra Rooker, Quincy You, Prof. Dr. Caren L. Freel Meyers, Prof. Dr. Pinghua Liu

Journal:

Year:

2011

File:

PDF, 581 KB

2011

19

Activation Mechanisms of Nucleoside Phosphoramidate Prodrugs

Freel Meyers, Caren L., Borch, Richard F.

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 196 KB

english, 2000

20

Defining critical residues for substrate binding to 1-deoxy- d -xylulose 5-phosphate synthase - active site substitutions stabilize the predecarboxylation intermediate C2α-lactylthiamin diphosphate

Brammer Basta, Leighanne A., Patel, Hetalben, Kakalis, Lazaros, Jordan, Frank, Freel Meyers, Caren L.

Journal:

Year:

2014

Language:

english

File:

PDF, 1.54 MB

english, 2014

21

Novel Method for the Immobilization of Nucleotides

Freel Meyers, Caren L., Borch, Richard F.

Journal:

Organic Letters

Year:

2003

Language:

english

File:

PDF, 71 KB

english, 2003

22

Revealing Substrate Promiscuity of 1-Deoxy- d -xylulose 5-Phosphate Synthase

Brammer, Leighanne A., Meyers, Caren Freel

Journal:

Organic Letters

Year:

2009

Language:

english

File:

PDF, 337 KB

english, 2009

23

Pharmacological activation of myosin II paralogs to correct cell mechanics defects

Surcel, Alexandra, Ng, Win Pin, West-Foyle, Hoku, Zhu, Qingfeng, Ren, Yixin, Avery, Lindsay B., Krenc, Agata K., Meyers, David J., Rock, Ronald S., Anders, Robert A., Freel Meyers, Caren L., Robinson,

Journal:

Proceedings of the National Academy of Sciences

Year:

2015

Language:

english

File:

PDF, 1.32 MB

english, 2015

24

Characterization of NovP and NovN: Completion of Novobiocin Biosynthesis by Sequential Tailoring of the Noviosyl Ring

Caren L. Freel Meyers, Markus Oberthür, Hui Xu, Lutz Heide, Daniel Kahne, Christopher T. Walsh

Journal:

Angewandte Chemie International Edition

Year:

2004

Language:

english

File:

PDF, 157 KB

english, 2004

25

ChemInform Abstract: A Novel Method for the Preparation of Nucleoside Diphosphates.

Caren L. Freel Meyers, Richard F. Borch

Journal:

Year:

2002

File:

PDF, 27 KB

2002

26

Antibiotic Glycosyltransferases: Antibiotic Maturation and Prospects for Reprogramming †

Walsh, Christopher, Freel Meyers, Caren L., Losey, Heather C.

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 531 KB

english, 2003

27

Competence of Thiamin Diphosphate-Dependent Enzymes with 2′-Methoxythiamin Diphosphate Derived from Bacimethrin, a Naturally Occurring Thiamin Anti-vitamin

Nemeria, Natalia S., Shome, Brateen, DeColli, Alicia A., Heflin, Kathryn, Begley, Tadhg P., Meyers, Caren Freel, Jordan, Frank

Journal:

Year:

2016

Language:

english

File:

PDF, 4.13 MB

english, 2016

28

Targeting DXP synthase in human pathogens: enzyme inhibition and antimicrobial activity of butylacetylphosphonate

Smith, Jessica M, Warrington, Nicole V, Vierling, Ryan J, Kuhn, Misty L, Anderson, Wayne F, Koppisch, Andrew T, Freel Meyers, Caren L

Journal:

The Journal of Antibiotics

Year:

2014

Language:

english

File:

PDF, 624 KB

english, 2014

29

Oxidative decarboxylation of pyruvate by 1-deoxy-D-xyulose 5-phosphate synthase, a central metabolic enzyme in bacteria

DeColli, Alicia A., Nemeria, Natasha S., Majumdar, Ananya, Gerfen, Gary J., Jordan, Frank, Freel Meyers, Caren L.

Journal:

Journal of Biological Chemistry

Year:

2018

Language:

english

File:

PDF, 999 KB

english, 2018

30

Semi-solid prodrug nanoparticles for long-acting delivery of water-soluble antiretroviral drugs within combination HIV therapies

Hobson, James J., Al-khouja, Amer, Curley, Paul, Meyers, David, Flexner, Charles, Siccardi, Marco, Owen, Andrew, Meyers, Caren Freel, Rannard, Steve P.

Journal:

Nature Communications

Year:

2019

Language:

english

File:

PDF, 1.28 MB

english, 2019

31

Characterization of the Aminocoumarin Ligase SimL from the Simocyclinone Pathway and Tandem Incubation with NovM,P,N from the Novobiocin Pathway †

Pacholec, Michelle, Freel Meyers, Caren L., Oberthür, Markus, Kahne, Daniel, Walsh, Christopher T.

Journal:

Year:

2005

Language:

english

File:

PDF, 135 KB

english, 2005

32

A Novel Method for the Preparation of Nucleoside Triphosphates from Activated Nucleoside Phosphoramidates

Wu, Weidong, Freel Meyers, Caren L., Borch, Richard F.

Journal:

Organic Letters

Year:

2004

Language:

english

File:

PDF, 78 KB

english, 2004

33

A Novel Method for the Preparation of Nucleoside Diphosphates

Meyers, Caren L. Freel, Borch, Richard F.

Journal:

Organic Letters

Year:

2001

Language:

english

File:

PDF, 55 KB

english, 2001

34

Hydroxybenzaldoximes Are D -GAP-Competitive Inhibitors of E. coli 1-Deoxy- D -Xylulose-5-Phosphate Synthase

Bartee, David, Morris, Francine, Al-khouja, Amer, Freel Meyers, Caren L.

Journal:

Year:

2015

Language:

english

File:

PDF, 746 KB

english, 2015

35

IspG-Catalyzed Positional Isotopic Exchange in Methylerythritol Cyclodiphosphate of the Deoxyxylulose Phosphate Pathway: Mechanistic Implications

Dr. Youli Xiao, Debra Rooker, Quincy You, Prof. Dr. Caren L. Freel Meyers, Prof. Dr. Pinghua Liu

Journal:

Year:

2011

Language:

english

File:

PDF, 242 KB

english, 2011

36

Antibiotic Glycosyltransferases: Antibiotic Maturation and Prospects for Reprogramming

Christopher Walsh, Caren L. Freel Meyers, Heather C. Losey

Journal:

Year:

2003

File:

PDF, 51 KB

2003

37

The 1.6-Å resolution crystal structure of NovW: A 4-keto-6-deoxy sugar epimerase from the novobiocin biosynthetic gene cluster of Streptomyces spheroides

Piotr Jakimowicz, Mónica Tello, Caren L. Freel Meyers, Christopher T. Walsh, Mark J. Buttner, Robert A. Field, David M. Lawson

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2006

Language:

english

File:

PDF, 140 KB

english, 2006

38

Synthesis and Biological Activity of Novel 5-Fluoro-2‘-deoxyuridine Phosphoramidate Prodrugs

Freel Meyers, Caren L., Hong, Liping, Joswig, Carolyn, Borch, Richard F.

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 78 KB

english, 2000

39

Physiologically Based Pharmacokinetic Modelling to Inform Development of Intramuscular Long-Acting Nanoformulations for HIV

Rajoli, Rajith K. R., Back, David J., Rannard, Steve, Freel Meyers, Caren L., Flexner, Charles, Owen, Andrew, Siccardi, Marco

Journal:

Clinical Pharmacokinetics

Year:

2015

Language:

english

File:

PDF, 1.08 MB

english, 2015

40

Resistance to the antimicrobial agent fosmidomycin and an FR900098 prodrug through mutations in deoxyxylulose phosphate reductoisomerase (Dxr)

Armstrong, Christopher M., Meyers, David J., Imlay, Leah S., Meyers, Caren Freel, Odom, Audrey R.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2015

Language:

english

File:

PDF, 848 KB

english, 2015

41

A novel lipoate attachment enzyme is shared by Plasmodium and Chlamydia species

Afanador, Gustavo A., Guerra, Alfredo J., Swift, Russell P., Rodriguez, Ryan E., Bartee, David, Matthews, Krista A., Schön, Arne, Freire, Ernesto, Freel Meyers, Caren L., Prigge, Sean T.

Journal:

Molecular Microbiology

Year:

2017

Language:

english

File:

PDF, 1.51 MB

english, 2017

42

Targeting the Unique Mechanism of Bacterial 1-deoxy-D-xylulose 5-phosphate (DXP) Synthase

Bartee, David, Freel Meyers, Caren L.

Journal:

Year:

2018

Language:

english

File:

PDF, 1.11 MB

english, 2018

43

Growth medium-dependent antimicrobial activity of early stage MEP pathway inhibitors

Sanders, Sara, Bartee, David, Harrison, Mackenzie J., Phillips, Paul D., Koppisch, Andrew T., Freel Meyers, Caren L., Virolle, Marie-Joelle

Journal:

Year:

2018

Language:

english

File:

PDF, 2.59 MB

english, 2018

44

Assembly of Dimeric Variants of Coumermycins by Tandem Action of the Four Biosynthetic Enzymes CouL, CouM, CouP, and NovN †

Freel Meyers, Caren L., Oberthür, Markus, Heide, Lutz, Kahne, Daniel, Walsh, Christopher T.

Journal:

Year:

2004

Language:

english

File:

PDF, 784 KB

english, 2004

45

Characterization of NovP and NovN: Completion of Novobiocin Biosynthesis by Sequential Tailoring of the Noviosyl Ring

Caren L. Freel Meyers, Markus Oberthür, Hui Xu, Lutz Heide, Daniel Kahne, Christopher T. Walsh

Journal:

Angewandte Chemie

Year:

2004

Language:

english

File:

PDF, 156 KB

english, 2004

46

Versatile 1 H− 31 P− 31 P COSY 2D NMR Techniques for the Characterization of Polyphosphorylated Small Molecules

Majumdar, Ananya, Sun, Yan, Shah, Meha, Freel Meyers, Caren L.

Journal:

Journal of Organic Chemistry

Year:

2010

Language:

english

File:

PDF, 2.67 MB

english, 2010

47

Toward Understanding the Chemistry and Biology of 1-Deoxy- d -xylulose 5-Phosphate (DXP) Synthase: A Unique Antimicrobial Target at the Heart of Bacterial Metabolism

Bartee, David, Freel Meyers, Caren L.

Journal:

Accounts of Chemical Research

Year:

2018

Language:

english

File:

PDF, 3.62 MB

english, 2018

48

Bisphosphonamidate Clodronate Prodrug Exhibits Potent Anticancer Activity in Non-Small-Cell Lung Cancer Cells

Webster, Marie R., Zhao, Ming, Rudek, Michelle A., Hann, Christine L., Freel Meyers, Caren L.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.31 MB

english, 2011

49

IspG Converts an Epoxide Substrate Analogue to ( E )-4-Hydroxy-3-methylbut-2-enyl Diphosphate: Implications for IspG Catalysis in Isoprenoid Biosynthesis

Nyland II, Rodney L., Xiao, Youli, Liu, Pinghua, Freel Meyers, Caren L.

Journal:

Journal of the American Chemical Society

Year:

2009

Language:

english

File:

PDF, 325 KB

english, 2009

To build up a library is to create a life. It’s never just a random collection of books.

— Carlos María Domínguez

Official channel

Z-Library Desktop Launcher

Z-Library Since 2009 support@1delivery.pm

EnglishРусскийEspañolItalianoελληνικάاللغة العربيةBahasa IndonesiaBahasa Malaysiaहिन्दीDeutschFrançaisPortuguêsУкраїнськаPolski中文繁體中文日本語Tiếng ViệtAzərbaycan DiliՀայոց լեզուภาษาไทยTürk Diliქართველიবাংলাپښتوతెలుగుاردو한국어SrpskiБългарски